Paracetamol is an antipyretic drug which having 2 polymorphic forms, i.e. polymorph I (monoclinic form) and polymorph II (orthorhombic form). In market paracetamol polymorph I (monoclinic form) tablet is available. The main objective of studying different polymorphs of Paracetamol was to identify suitable polymorphic form for development of stable and effective dosage form and studying different physicochemical properties of Paracetamol polymorphs. Paracetamol polymorph study; developed orthorhombic polymorphic by using two different methods i.e. crystallization of orthorhombic paracetamol by melting monoclinic paracetamol and second method was preparing orthorhombic paracetamol by using an anhydrous nitrogen atmosphere. In that study second method was found to be suitable for developing orthorhombic polymorphic form on the basis of melting point study and PXRD study.IP Grade Paracetamol did not show result and then used USP Grade Paracetamol. By using USP Grade Paracetamol orthorhombic form was developed and comparative flow properties study of paracetamol polymorph carried out, in that orthorhombic form shows better flow properties and higher percentage of drug release after 30 minute.
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